Reaktion #58479

Reaktionsgleichung

4-Cyano-tetrahydro furane 3-carboxylic acid methyl ester

SOCl2

water

→

4-cyano-2,5-dihydro furane 3-carboxylic acid methyl ester

Ausbeute 90.0%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with benzene
2. 2
   SonstigeCombined extracts were dried
3. 3
   Einengenconcentrated in vacuo

Vorschrift

4-Cyano-tetrahydro furane 3-carboxylic acid methyl ester was dissolved in 4.9 ml of pyridine and treated with 4.4 ml (60 mmol) of SOCl2 during 90 min under nitrogen at 4° C. The resulting solution was warmed to room temperature, stirred for 6 hours and poured into 40 ml water at 4° C. and extracted with benzene. Combined extracts were dried and concentrated in vacuo to give 90% yield of 4-cyano-2,5-dihydro furane 3-carboxylic acid methyl ester.

Quelle