Reaktion #58478

Reaktionsgleichung

KCN

4-oxo-tetrahydro furane 3-carboxylic acid methyl ester

H2SO4

→

4-cyano-tetrahydro furane 3-carboxylic acid methyl ester

Lösungsmittel

water

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the organic solution was separated
2. 2
   Waschenthe salts were washed twice with benzene
3. 3
   Trocknendried over sodium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a stirred solution of 3.9 g (60 mmol) KCN in 5.5 ml of water at 4° C., a solution of 2.9 g (20 mmol) of 4-oxo-tetrahydro furane 3-carboxylic acid methyl ester in ether (26 ml) was added. To the precipitate of salts, 3.5 ml H2SO4 (18 N) was added and stirred for 16 hours. Then the organic solution was separated, the salts were washed twice with benzene, dried over sodium sulfate and concentrated in vacuo to give 4-cyano-tetrahydro furane 3-carboxylic acid methyl ester.

Quelle