Reaktion #58455

ord-bfa1eb39978b4e89b76325180d974536

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1ccc(F)cc1
2-bromo-4′-fluoroacetophenone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1ccc(F)cc1
title compound
Ausbeute 96.9%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1ccc(F)cc1
(RS)-2-[2-(4-Fluoro-phenyl)-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl ester
Ausbeute 96.9%

Edukte

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1ccc(F)cc1
2-bromo-4′-fluoroacetophenone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (3.83 g) was prepared from (RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (2.54 g) and 2-bromo-4′-fluoroacetophenone (2.26 g) according to the method of description 36.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423052B2uspto-grants-2008_09