Reaktion #58452

ord-f27181ed3be844dead513c3355c44c1e

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
NCC(=O)c1ccc(F)cc1
2-amino-1-(4-fluoro-phenyl)-ethanone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)NCC(=O)c1ccc(F)cc1
title compound
Ausbeute 61.9%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)NCC(=O)c1ccc(F)cc1
(RS)-2-{[2-(4-Fluoro-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl ester
Ausbeute 61.9%

Edukte

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
NCC(=O)c1ccc(F)cc1
2-amino-1-(4-fluoro-phenyl)-ethanone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (0.77 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (0.80 g) and 2-amino-1-(4-fluoro-phenyl)-ethanone (0.63 g) according to the method of description 20.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423052B2uspto-grants-2008_09