Reaktion #5842

Reaktionsgleichung

3,4-dimethoxyaniline

5-isoquinolinesulfonyl chloride

HCl

→

title compound

Ausbeute 82.0%

N-(3,4-Dimethoxyphenyl)-5-Isoquinolinesulfonamide

Ausbeute 82.0%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGfurther stirred at a room temperature overnight
2. 2
   SonstigeAfter evaporating off the pyridine under a reduced pressure
3. 3
   Extraktionthe mixture was extracted twice with 50 ml of chloroform/isopropanol (10:1)
4. 4
   TrocknenThe extract was dried over magnesium sulfate
5. 5
   Sonstigeevaporated under a reduced pressure
6. 6
   Sonstigeto remove the solvent
7. 7
   workup.ADDITIONTo the resulting residue was added 20 ml of benzene/chloroform (3:1)
8. 8
   Temperaturthe mixture was slightly warmed
9. 9
   Sonstigecollected

Vorschrift

3.06 g of 3,4-dimethoxyaniline was dissolved in 30 ml of pyridine, to the solution was added in small portions 5.28 g of 5-isoquinolinesulfonyl chloride.HCl with stirring under ice cooling, and the mixture was stirred for 30 minutes, and further stirred at a room temperature overnight. After evaporating off the pyridine under a reduced pressure and additing 20 ml of water, the mixture was extracted twice with 50 ml of chloroform/isopropanol (10:1). The extract was dried over magnesium sulfate and evaporated under a reduced pressure to remove the solvent. To the resulting residue was added 20 ml of benzene/chloroform (3:1), and the mixture was slightly warmed and collected to obtain 5.64 g of the title compound as colorless crystals.

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