Reaktion #58400

ord-51a5a36a1d9d4394894e28c02dcdbd7b

Reaktionsgleichung

COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N.O=C(O)C(F)(F)F
[4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt
CCCS(=O)(=O)Cl
1-propanesulfonyl chloride
CCCS(=O)(=O)N1CCC(Nc2ccc(C(=O)c3cc(F)ccc3OC)c(N)n2)CC1
title compound
CCCS(=O)(=O)N1CCC(Nc2ccc(C(=O)c3cc(F)ccc3OC)c(N)n2)CC1
{2-Amino-6-[1-(propane-1-sulfonyl)-piperidin-4-ylamino]-pyridin-3-yl}-(5-fluoro-2-methoxy-phenyl)-methanone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and 1-propanesulfonyl chloride (Aldrich 97%) using the procedure described in Example 24. HRMS, observed 451.1817, Calcd for (M+H)+: 451.1810.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423051B2uspto-grants-2008_09