Reaktion #58389

ord-5f7fa57ec4de451286957bddd0eb70fe

Reaktionsgleichung

Nc1nc(NC2CCNCC2)ccc1C(=O)c1ccccc1F
[2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone
CC(=O)Cl
acetyl chloride
→
CC(=O)N1CCC(Nc2ccc(C(=O)c3ccccc3F)c(N)n2)CC1
title compound
CC(=O)N1CCC(Nc2ccc(C(=O)c3ccccc3F)c(N)n2)CC1
1-{4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone

Edukte

Nc1nc(NC2CCNCC2)ccc1C(=O)c1ccccc1F
[2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone
CC(=O)Cl
acetyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone (Example 9) and acetyl chloride (Aldrich 98.5%) using the procedure described in Example 12. HRMS, observed: 356.1655, Calcd for M+: 356.1649.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423051B2uspto-grants-2008_09