Reaktion #58322

Reaktionsgleichung

sodium hydroxide

7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

7-Methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

compound 1

7-Methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

pyridinium hydrochloride

→

beige-coloured powder

Ausbeute 86.8%

7-Hydroxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

Ausbeute 86.8%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction medium is cooled
2. 2
   WaschenA precipitate forms, which is washed with water and with dichloromethane
3. 3
   Sonstigedried under reduced pressure

Vorschrift

A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.

Quelle