Reaktion #5823

Reaktionsgleichung

N-benzyloxycarbonyltyrosine

N-phenylpiperazine

DCC

→

title compound

Ausbeute 58.6%

1-(N-Benzyloxycarbonyltyrosyl)-4-Phenylpiperazine

Ausbeute 58.6%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationPrecipitated insoluble matter was filtered off
2. 2
   Einengenthe filtrate was concentrated under a reduced pressure
3. 3
   Sonstigeresulting residue
4. 4
   Wascheneluted with hexane/ethyl acetate (1:1 to 1:2)

Vorschrift

12.3 g of N-benzyloxycarbonyltyrosine and 6.6 g of N-phenylpiperazine were dissolved in 150 ml of methylene chloride, and to the solution was added 8.4 g of DCC, and the mixture was stirred at a room temperature for 5 hours. Precipitated insoluble matter was filtered off and the filtrate was concentrated under a reduced pressure, and resulting residue was applied to a silica gel column and eluted with hexane/ethyl acetate (1:1 to 1:2) to obtain 10.5 g of the title compound in a colorless amorphous form.

Quelle