Reaktion #581649

Reaktionsgleichung

product

Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate

HCl

→

4-hydroxy-1,1-dimethyl-2(1 H)-naphthalenone

Lösungsmittel

dioxane

ethyl acetate

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 6 hours
2. 2
   WaschenThe organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4)
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe residue was triturated with ether
6. 6
   Filtrationfiltered

Vorschrift

A solution of the product of Example 9E (2.25 g, 8.65 mmol) in dioxane (50 mL) was treated with 1 N HCl solution (60 mL) and the mixture was stirred at reflux for 6 hours, cooled to 25° C., diluted with ethyl acetate and water. The organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4), filtered and concentrated in vacuo. The residue was triturated with ether and filtered.

Quelle