Reaktion #58164

Reaktionsgleichung

4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

N-chlorosuccinimide

→

4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine

Ausbeute 83.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was cooled down
2. 2
   Filtrationthe white solid was filtered
3. 3
   Waschenwashed with dichloromethane (300 mL)
4. 4
   Sonstigedried

Vorschrift

Following the procedure in Pdulo, J. S.; Saxena, N. K.; Nassiri, M. R.; Turk, S. R.; Drach, J. C.; Townsend, L. B. J. Med. Chem. 31:2086 (1988), 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (Example 1A, 20. g, 0.13 mol) was suspended in anhydrous dichloromethane (500 mL), followed by addition of N-chlorosuccinimide (20.8 g, 0.160 mol). The reaction mixture was refluxed at 43° C. for 8 hours. The reaction was cooled down, and the white solid was filtered, washed with dichloromethane (300 mL), and dried to give 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine (20 g, 83%)

Quelle