Reaktion #581579

Reaktionsgleichung

4-Aminobenzoic acid ethyl ester

triethylamine

4′-trifluoromethylbiphenyl-2-carboxylic acid

4′-trifluoromethylbiphenyl-2-carboxylic acid chloride

→

title compound

4-[(4′-Trifluoromethylbiphenyl-2-carbonyl)amino]benzoic acid ethyl ester

Lösungsmittel

methylene chloride

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   WaschenThe reaction mixture was washed with 2N hydrochloric acid and saturated brine
3. 3
   Trocknendried over sodium sulfate
4. 4
   Einengenconcentrated

Vorschrift

4-Aminobenzoic acid ethyl ester (0.568 g) and triethylamine (0.570 g) were dissolved in methylene chloride (20 mL), and to this solution was dropwise added a solution of 4′-trifluoromethylbiphenyl-2-carboxylic acid chloride, which is prepared from 4′-trifluoromethylbiphenyl-2-carboxylic acid (1.00 g) in a similar manner to Example 1d), in methylene chloride under ice-cooling. The solution was stirred at room temperature for 2 hours, followed by addition of methylene chloride (100 mL). The reaction mixture was washed with 2N hydrochloric acid and saturated brine, dried over sodium sulfate and concentrated to give the title compound (1.43 g).

Quelle