Reaktion #581562

Reaktionsgleichung

4′-trifluoromethylbiphenyl-2-carboxylic acid

dimethylformamide

oxalyl chloride

→

title compound

4′-Trifluoromethylbiphenyl-2-carboxylic acid chloride

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   Sonstigethe solvent was removed by evaporation
3. 3
   workup.DISTILLATIONAfter azeotropic distillation with toluene
4. 4
   Sonstigethe residue was dried in vacuo

Vorschrift

To a mixture of 4′-trifluoromethylbiphenyl-2-carboxylic acid (5.06 g), dimethylformamide (catalytic amount) and methylene chloride (30 mL) was added dropwise oxalyl chloride (2.43 mL) under ice-cooling. The mixture was stirred at room temperature for 100 minutes and the solvent was removed by evaporation. After azeotropic distillation with toluene, the residue was dried in vacuo to give the title compound (5.40 g).

Quelle