Reaktion #58126

ord-94fd441b856b4ad28e1d48d86cfcbbc3

Reaktionsgleichung

CCOC(O)C(=O)c1ccc(OCc2ccccc2)c(C(=O)OC)c1
methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate
NC1(Cc2ccccc2)CC1
1-benzyl-cyclopropylamine
O=C([O-])C(F)(F)F
trifluoroacetate
→
OCc1cc(C(O)CNC2(Cc3ccccc3)CC2)ccc1O
4-[2-(1-benzyl-cyclopropylamino)-1-hydroxy-ethyl]-2-hydroxymethyl-phenol

Edukte

CCOC(O)C(=O)c1ccc(OCc2ccccc2)c(C(=O)OC)c1
methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate
NC1(Cc2ccccc2)CC1
1-benzyl-cyclopropylamine
O=C([O-])C(F)(F)F
trifluoroacetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to general method 5 from 344 mg (1 mmol) methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate and 147 mg (1 mmol) 1-benzyl-cyclopropylamine. Yield: 184 mg (43%, trifluoroacetate); mass spectroscopy: [M+H]+=314.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07423035B2uspto-grants-2008_09