Reaktion #580575

Reaktionsgleichung

6-o-tolylnicotinaldehyde

sodium borohydride

→

product

Ausbeute 100.0%

(6-o-Tolylpyridin-3-yl)methanol

Ausbeute 100.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min
2. 2
   Sonstigepartitioned between dichloromethane and brine
3. 3
   ExtraktionThe organic extract
4. 4
   Trocknenwas dried over magnesium sulfate
5. 5
   Einengenconcentrated

Vorschrift

To a solution of 1.070 g (5.43 mmol) of 6-o-tolylnicotinaldehyde in 19 mL of ethanol at 0-5° C., was added 287 mg(7.5 mmol, 1.4 eq.) of sodium borohydride. After 2 h, the reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min, partitioned between dichloromethane and brine. The organic extract was dried over magnesium sulfate and concentrated to give the indicated product as a colorless oil, 1.08 g, 100% yield.

Quelle