Reaktion #580228

Reaktionsgleichung

dry ice

hydrochloric acid

dry ice

magnesium

1-(trans-4-n-propylcyclohexyl)-4-bromobenzene

→

p-(trans-4-propylcyclohexyl)benzoic acid

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONwere dissolved
2. 2
   workup.ADDITIONwas added to the resultant
3. 3
   Sonstigeto give a precipitate
4. 4
   Filtrationthe precipitate was filtered
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried
7. 7
   Sonstigerecrystallized from toluene

Vorschrift

A Grignard reagent was prepared from a solution of 50 ml of dried tetrahydrofuran in which 0.88 g (36.7 mmol) of magnesium and 10.0 g (35.6 mmol) of 1-(trans-4-n-propylcyclohexyl)-4-bromobenzene were dissolved, and the Grignard reagent was put into dry ice. After vaporizing the dry ice, hydrochloric acid was added to the resultant to give a precipitate, and the precipitate was filtered, washed with water, dried, and recrystallized from toluene to give 7.5 g (30.5 mmol) of p-(trans-4-propylcyclohexyl)benzoic acid.

Quelle