Reaktion #579560

Reaktionsgleichung

sodium triacetoxyborohydride

1,2-dichloroethane

6-(4-formyl-phenoxy)-nicotinamide

6-(4-Formyl-phenoxy)-nicotinamide

compound

6-(4-Formyl-phenoxy)-nicotinamide

acetic acid

2-phenyl-pyrrolidine

→

title compound

Ausbeute 3.9%

(±)-6-[4-(2-Phenyl-pyrrolidin-1-ylmethyl)-phenoxy]-nicotinamide hydrochloride

Ausbeute 3.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurify the reaction mixture by ion exchange chromatography (SCX resin, methanol→2 M ammonia/methanol)
2. 2
   Einengenconcentrate
3. 3
   workup.DISSOLUTIONDissolve the residue in 1,4-dioxane
4. 4
   workup.ADDITIONtreated with 4 N hydrochloric acid in dioxane
5. 5
   SonstigeIsolate the white precipitate
6. 6
   Filtrationby vacuum filtration
7. 7
   Sonstigeafter approximately 3 min.
8. 8
   workup.DISSOLUTIONDissolve the residue in 1,4-dioxane
9. 9
   Einengenconcentrate

Vorschrift

Combine 6-(4-formyl-phenoxy)-nicotinamide (compound of example 332, step 1) (0.150 g, 0.619 mmol), 2-phenyl-pyrrolidine (0.095 g, 0.64 mmol), sodium triacetoxyborohydride (0.194 g, 0.915 mmol) and acetic acid (0.051 mL, 0.891 mmol) in 1,2-dichloroethane (9.0 mL). After about 24 hours, purify the reaction mixture by ion exchange chromatography (SCX resin, methanol→2 M ammonia/methanol) and concentrate. Dissolve the residue in 1,4-dioxane and treated with 4 N hydrochloric acid in dioxane. Isolate the white precipitate by vacuum filtration. The solid became a yellowish syrup after approximately 3 min. on vacuum. Dissolve the residue in 1,4-dioxane and concentrate to provide 0.0100 g (3.9%) of the title compound as a white/yellow foam: high resolution mass spectrum (electrospray): m/z calc for C23H24N3O2 374.1869, found 374.1877; 1H NMR (methanol-d4): 8.63 (s, 1H), 8.35 (dd, 1H, J=1.5, 7.8 Hz), 7.64-7.44 (m, 7H), 7.24 (d, 2H, J=8.8 Hz), 7.11 (d, 1H, J=8.8 Hz), 4.69-4.60 (m, 1H), 4.28 (s, 2H), 3.75-3.66 (m, 1H), 3.58-3.47 (m, 1H), 2.71-2.60 (m, 1H), 2.45-2.22 (m, 3H).

Quelle