Reaktion #578782

Reaktionsgleichung

DIAD

2-chloro-5-nitro phenol

N-boc-4-piperidine methanol

PPh3

→

title compound

4-(2-chloro-5-nitro-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated in vacuo
2. 2
   workup.DISSOLUTIONdissolved in Et2O
3. 3
   Waschenwashed once with water
4. 4
   TrocknenThe organic layer was dried over Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo
7. 7
   workup.ADDITIONThe residue was treated with a mixture of hexanes and EtOAc (1:1)
8. 8
   Filtrationthe solid was filtered
9. 9
   SonstigeThe filtrate was evaporated
10. 10
    Sonstigethe residue was purified by silica gel column chromatography

Vorschrift

To a solution of 2-chloro-5-nitro phenol (10 g, 63.497 mmol), N-boc-4-piperidine methanol (13.67 g, 63.49 mmol), and PPh3 (16.63 g, 63.49 mmol) in 130 mL THF, cooled at −20° C. was added dropwise over 1.5 h a 50 mL THF solution containing DIAD (12.75 ml, 64.76 mmol). The mixture turned a deep red. The reaction was warmed gradually to RT and stirred for 18 h. The mixture was concentrated in vacuo, dissolved in Et2O, washed once with water, then NaHCO3 (sat). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The residue was treated with a mixture of hexanes and EtOAc (1:1) and the solid was filtered. The filtrate was evaporated and the residue was purified by silica gel column chromatography to yield the title compound as a yellow solid. MS (MH+)=NA; Calc'd 370.13 for C17H23ClN2O5.

Quelle