Reaktion #578634

ord-6cf33679a5894dc68afedec23714e852

Reaktionsgleichung

Cl.ClCc1cccnc1
3-picolylchloride hydrochloride
COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl
compound 18
COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl
(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-2-[1-(2-oxo-2H-chromen-7-ylmethyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride
→
COc1ccc(C2=NN(C3CCN(Cc4cccnc4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl.Cl
(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-2-(1-pyridin-3-ylmethyl-piperidin-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one dihydrochloride

Edukte

—
compound A1
Cl.ClCc1cccnc1
3-picolylchloride hydrochloride
COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl
compound 18
COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl
(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-2-[1-(2-oxo-2H-chromen-7-ylmethyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared from starting compound A1 and 3-picolylchloride hydrochloride as described for compound 18. M.p. 252-254° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07531540B2uspto-grants-2009_05