Reaktion #578627

Reaktionsgleichung

(4-Amino-3,5-dichloro-phenyl)-2-bromo-ethanone

compound 11

(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-2-[1-(4-nitro-phenyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

→

(4aS,8aR)-2-{1-[2-(4-Amino-3,5-dichloro-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture is extracted with diethyl ether
2. 2
   TrocknenThe ether solution is dried over magnesium sulfate
3. 3
   workup.ADDITIONAfter the addition of a saturated solution of hydrochloric acid in ether
4. 4
   Sonstigethe compound precipitates
5. 5
   SonstigeCrystallisation from tetrahydrofurane

Vorschrift

Prepared from (4-Amino-3,5-dichloro-phenyl)-2-bromo-ethanone and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. Crystallisation from tetrahydrofurane. M.p. 206° C. (decomposition).

Quelle