Reaktion #577286

Reaktionsgleichung

Ethyl acetate

5-bromo-2-fluorobenzonitrile

hydrazine

→

3-amino-5-bromoindazole

Ausbeute 96.5%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic layer was washed with water and brine
2. 2
   TrocknenThe organic layer was dried over sodium sulfate
3. 3
   SonstigeThe organic solvent was evaporated under reduced pressure

Vorschrift

To a solution of 5-bromo-2-fluorobenzonitrile (0.40 g, 2.0 mmol.) in ethanol (3 mL) was added hydrazine (0.64 g, 20 mmol.). The reaction mixture was heated in a microwave reactor at 140° C. for 20 minutes. Ethyl acetate (100 mL) was added. The organic layer was washed with water and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure to yield 3-amino-5-bromoindazole 165 (0.41 g, 1.93 mmol.). The crude product was used in the next step without further purification.

Quelle