Reaktion #57722

Reaktionsgleichung

2-amino-4-chloro-benzenethiol

ethyl triethoxyacetate

→

5-chloro-benzothiazole-2-carboxylic acid ethyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled
2. 2
   Sonstigetriturated with hexane
3. 3
   FiltrationFiltration

Vorschrift

To 2-amino-4-chloro-benzenethiol (1 g) was added ethyl triethoxyacetate (3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 392 mg of 5-chloro-benzothiazole-2-carboxylic acid ethyl ester as a white solid.

Quelle