Reaktion #577213

Reaktionsgleichung

4-cyano-4′-hydroxybiphenyl

bromide

potassium carbonate

butanone

→

4-allyloxy-4′-cyanobiphenyl

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA reaction mixture obtained
2. 2
   Temperaturwas refluxed for 7 hours
3. 3
   Sonstigewas then separated
4. 4
   WaschenAn organic layer was washed with water
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   Sonstigeto obtain a residue, which
8. 8
   Sonstigewas purified by silica gel column chromatography
9. 9
   Sonstigesubjected to recrystallization from ethanol

Vorschrift

A reaction mixture obtained by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of ally bromide and 25 g of potassium carbonate to 250 mL of butanone was refluxed for 7 hours. Water was added to the reaction mixture, which was then separated. An organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a residue, which was purified by silica gel column chromatography using toluene as an elusion solvent and then subjected to recrystallization from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Quelle