Reaktion #577171

Reaktionsgleichung

PyBroP

4′-Trifluoromethyl-biphenyl-2-carboxylic acid

1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester

DIEA

→

title compound

Ausbeute 54.4%

1-Ethyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester

Ausbeute 54.4%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction mixture was stirred for another 3 hours
2. 2
   FiltrationThe precipitate was filtered off
3. 3
   Waschenwashed with cold DCM

Vorschrift

4′-Trifluoromethyl-biphenyl-2-carboxylic acid (5.04 g, 18.95 mmol) and 1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester (4.00 g, 17.23 mmol) were dissolved in DCM (100 mL). DIEA (8 g, 61.8 mmol) was added to the above mixture and the mixture was stirred at room temperature for 5 minutes. PyBroP (9.63 g, 20.67 mmol) was added to the above solution in one portion. The reaction mixture was stirred for another 3 hours. The precipitate was filtered off and washed with cold DCM to provide the title compound (4.5 g, 54.4%).

Quelle