Reaktion #577131

ord-115ebaf4e5d94608ab014f3be21bf72b

Reaktionsgleichung

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine
→
Cc1cccc(-c2n[nH]cc2-c2ccncn2)c1
4-[3-(3-methylphenyl)-1H-pyrazol-4-yl]pyrimidine

Edukte

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
—
1-methyl-3-(4′-pyrimidinylacetyl)benzene
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis compound was prepared by the same procedure
  2. 2
    Sonstigeprepared

Vorschrift

This compound was prepared by the same procedure as described for Example A-208 except that 1-methyl-3-(4′-pyrimidinylacetyl)benzene (prepared as set forth in Step 1 of Example A-19 from 4-methyl-pyrimidine and methyl 3-methylbenzoate) was used in place of 4-fluorobenzoyl-4-pyridinyl methane.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06979686B1uspto-grants-2005_12