Reaktion #57667

Reaktionsgleichung

5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

iodomethane

K2CO3

→

5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

Ausbeute 99.3%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe mixture was washed with brine
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe combined ethyl acetate solution was washed with brine
4. 4
   SonstigeRemoval of the solvent in vacuo

Vorschrift

To 120 mg of 5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of iodomethane, 200 mg of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent in vacuo gave 125 mg (99% yield) of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as off-white solid.

Quelle