Reaktion #576258

Reaktionsgleichung

benzyl-2-(N-FMOC-L-valyloxy)stearate

→

2-(N-FMOC-L-valyloxy) stearic acid

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Waschenwashed with ethyl acetate and 1,4-dioxane
3. 3
   SonstigeThe solution was evaporated under reduced pressure
4. 4
   Sonstigethe product was isolated by silica gel column chromatography

Vorschrift

A solution of benzyl-2-(N-FMOC-L-valyloxy)stearate (4.4 g, 6.2 mmole) in 50 ml ethyl acetate was hydrogenated with 10% palladium on charcoal (0.5 g) with normal pressure for two hours. The catalyst was filtered and washed with ethyl acetate and 1,4-dioxane. The solution was evaporated under reduced pressure and the product was isolated by silica gel column chromatography. Yield: 3.4 g

Quelle