Reaktion #576257

Reaktionsgleichung

benzyl-2-hydroxystearate

N-FMOC-L-valine

DCC

→

benzyl-2-(N-FMOC-L-valyloxy)stearate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to 5° C.
2. 2
   Filtrationthe urethane was filtered
3. 3
   SonstigeThe filtrate was evaporated
4. 4
   Sonstigethe product was isolated by silica gel column chromatography

Vorschrift

To a solution of benzyl-2-hydroxystearate (3.2 g, 8.2 mmole), N-FMOC-L-valine (3.4 g, 10 mmole) and DMAP (0.12 g, 1 mmole) in 80 ml dichloromethane was added a solution of DCC (2.5 g, 12 mmole) and the mixture was stirred overnight at room temperature. The mixture was cooled to 5° C. and the urethane was filtered. The filtrate was evaporated and the product was isolated by silica gel column chromatography. Yield: 4.5 g

Quelle