Reaktion #576252

Reaktionsgleichung

2′,3′-dideoxy-3′-fluoro-5′-O-[1-(N-CBz-L-valyloxy)-2-stearoyloxy-3-propyloxy carbonyl]guanosine

→

titled product

2′,3′-dideoxy-3′-fluoro-5′-O-[1-(L-valyloxy)-2-stearoyloxy-3-propyloxy carbonyl]guanosine

Lösungsmittel

methanol

ethyl acetate

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationIt was then filtered
2. 2
   Sonstigethe filtrate was evaporated

Vorschrift

2′,3′-dideoxy-3′-fluoro-5′-O-[1-(N-CBz-L-valyloxy)-2-stearoyloxy-3-propyloxy carbonyl]guanosine (190 mg), was dissolved in a mixed solvent of methanol (6 ml), ethyl acetate (2 ml) and acetic acid (1 ml). To the solution was added palladium black (30 mg), and the reaction mixture was kept under hydrogen for 2 h. It was then filtered and the filtrate was evaporated and the titled product was isolated by silica gel column. 110 mg.

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