Reaktion #576248

Reaktionsgleichung

benzyl 5-(N-FMOC-L-valyloxy)-4-stearoyloxy-2-pentenoate

→

5-(N-FMOC-L-valyloxy)-4-stearoyloxy-pentanoic acid

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Waschenwashed with ethyl acetate and 1,4-dioxane
3. 3
   SonstigeThe solution was evaporated under reduced pressure Yield: 3.3 g=99%

Vorschrift

A solution of benzyl 5-(N-FMOC-L-valyloxy)-4-stearoyloxy-2-pentenoate (3.8 g, 4.69 mmole) in 50 ml ethyl acetate was hydrogenated with 10% palladium on charcoal (0.5 g) at normal pressure for five hours at room temperature. The catalyst was filtered and washed with ethyl acetate and 1,4-dioxane. The solution was evaporated under reduced pressure Yield: 3.3 g=99%

Quelle