Reaktion #57616

Reaktionsgleichung

4-hydroxy-2-benzofurancarboxylic acid methyl ester

2-bromopropane

potassium carbonate

→

methyl 4-isopropoxy-1-benzofuran-2-carboxylate

Ausbeute 100.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo
2. 2
   Extraktionthe residue was extracted with ethyl acetate
3. 3
   WaschenThe organic layer washed with water and brine
4. 4
   Trocknendried over sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 0.41 g (2.13 mmol) of 4-hydroxy-2-benzofurancarboxylic acid methyl ester in 7 mL of DMF was added 0.80 mL (8.54 mmol) of 2-bromopropane and 1.18 g (8.54 mmol) of potassium carbonate. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo, and the residue was extracted with ethyl acetate. The organic layer washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 0.49 g of methyl 4-isopropoxy-1-benzofuran-2-carboxylate. Yield ˜100%; m.p. 43-45° C.; MS: 235.1 (M+H)+.

Quelle