Reaktion #575723

Reaktionsgleichung

α-chloroparatoluic acid

diethylamine

→

α-diethylamino-paratoluic Acid

Ausbeute 63.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 48 hours
2. 2
   SonstigeThe solvent is evaporated off under vacuum
3. 3
   Sonstigethe residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40
4. 4
   SonstigeThe product is obtained in the form of a white powder
5. 5
   Sonstigeafter precipitation from hexane

Vorschrift

1 g (1 equivalent) of α-chloroparatoluic acid and 1.22 mL (2 equivalents) of diethylamine are placed in solution in 30 mL of acetonitrile. The reaction mixture is taken to reflux for 48 hours. The solvent is evaporated off under vacuum and the residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40 then pure MeOH). The product is obtained in the form of a white powder after precipitation from hexane. (Yield=63%).

Quelle