Reaktion #575305

Reaktionsgleichung

3-chloro-5-ethyl-4-hydroxy-1-naphthalenecarbaldehyde

chloromethyl methyl ether

N,N-diisopropylethylamine

→

captioned compound

3-Chloro-5-ethyl-4-methoxymethoxy-1-naphthalenecarbaldehyde

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereacted at room temperature for 4 hours
2. 2
   EinengenThe reaction solution was concentrated under reduced pressure
3. 3
   Sonstigethe resultant residue was purified by silica gel column chromatography (5% ethyl acetate/hexane)

Vorschrift

1.0 g of 3-chloro-5-ethyl-4-hydroxy-1-naphthalenecarbaldehyde, 0.91 ml of chloromethyl methyl ether and 3.5 ml of N,N-diisopropylethylamine were dissolved in 10 ml of dichloromethane, and reacted at room temperature for 4 hours. The reaction solution was concentrated under reduced pressure and the resultant residue was purified by silica gel column chromatography (5% ethyl acetate/hexane) to obtain 0.74 g of the captioned compound as a brown oily substance.

Quelle