Reaktion #575094

Reaktionsgleichung

potassium tert-butylate

2-amino-4-(2,4-dichlorophenyl)thiazole

2,4-dinitro-6-trifluoromethylchlorobenzene

tetrahydrofuran tert-butanol

→

N-[4-(2,4-Dichlorophenyl)-2-thiazolyl]-2,4-dinitro-6-trifluoromethylaniline

Ausbeute 90.0%

Lösungsmittel

water

acetic acid

tert-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthat addition
2. 2
   workup.WAITAfter a further hour at 0° C.
3. 3
   SonstigeThe precipitate was separated off
4. 4
   Waschenwashed with water until neutral and
5. 5
   Sonstigedried

Vorschrift

A solution of 7.4 g (66 mmol) of potassium tert-butylate in 50 ml of tert-butanol was added dropwise to a vigorously stirred mixture of 8.0 g (33 mmol) of 2-amino-4-(2,4-dichlorophenyl)thiazole, 9.8 g (37 mmol) of 2,4-dinitro-6-trifluoromethylchlorobenzene and 100 ml of tetrahydrofuran/tert-butanol (1:2) at 0° to 5° C. in such a way that addition was complete after 1 hour. After a further hour at 0° C., the mixture was slowly warmed, over the course of about 2 hours, to 20° C. The mixture was then adjusted to pH 4 with glacial acetic acid and diluted with about 1 l of water. The precipitate was separated off, washed with water until neutral and dried. Yield: 90%; melting point 125° to 130° C.

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