Reaktion #5748

Reaktionsgleichung

hydrochloric acid

2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-5-carboallyloxy-1,4-dihydropyridine

ammonium formate

triphenylphosphine

→

5-carboxy-2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-1,4-dihydropyridine

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated at the reflux temperature for 8 hours
2. 2
   Extraktionextracted with ethyl acetate (2×20 ml)
3. 3
   WaschenThe combined organic extracts are washed with aqueous sodium carbonate (1N; 3×10 l)
4. 4
   Sonstigethe basic washings are collected
5. 5
   ExtraktionThe resulting suspension is extracted with ethyl acetate (2×25 ml) the combined organic extracts
6. 6
   Sonstigeare dried on Na2SO4
7. 7
   Sonstigeevaporated under reduced pressure

Vorschrift

A suspension of 2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-5-carboallyloxy-1,4-dihydropyridine (g 0.27), palladium on charcoal (10% 6 mg), ammonium formate (mg 71) and triphenylphosphine (mg 3) in anhydrous 1,4-dioxane, is heated at the reflux temperature for 8 hours. The reaction mixture is cooled at room temperature, poured into an aqueous solution of hydrochloric acid (pH=2) and extracted with ethyl acetate (2×20 ml). The combined organic extracts are washed with aqueous sodium carbonate (1N; 3×10 l), the basic washings are collected, acidified to pH 5-6 with diluted aqueous hydrochloric acid. The resulting suspension is extracted with ethyl acetate (2×25 ml) the combined organic extracts are dried on Na2SO4 and evaporated under reduced pressure to give mg 160 of 5-carboxy-2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-1,4-dihydropyridine as an amorphous solid.

Quelle