Reaktion #574325

Reaktionsgleichung

5-chloro-2-mercaptobenzothiazole

sodium hydride

2-chloroethyl ethyl ether

→

desired compound

Ausbeute 80.0%

5-Chloro-2-[(2-ethoxyethyl)thio]benzothiazole

Ausbeute 80.0%

Lösungsmittel

—

aqueous solution

chloroform

sodium chloride

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGand the mixture was stirred for two hours
2. 2
   workup.ADDITIONwas added
3. 3
   workup.STIRRINGAfter shaking
4. 4
   Waschenwashing the mixture
5. 5
   Sonstigethe chloroform layer was separated
6. 6
   Trocknendried over anhydrous magnesium sulfate
7. 7
   Einengenconcentrated under reduced pressure
8. 8
   SonstigeThe residue thus obtained
9. 9
   Sonstigewas separated
10. 10
    Sonstigepurified by silica gel chromatography

Vorschrift

5.00 g (24.8 mmol) of 5-chloro-2-mercaptobenzothiazole was dissolved in 25 ml of N,N-dimethylformamide. 710 mg (29.6 mmol) of sodium hydride was added to the above solution and the mixture was stirred for one hour. Then, 5.44 ml (49.6 mmol) of 2-chloroethyl ethyl ether was added to the resulting suspension. and the mixture was stirred for two hours while heating at 50° C. The reaction mixture was diluted with 500 ml of chloroform and 500 ml of 20% aqueous solution of sodium chloride was added thereto. After shaking and washing the mixture, the chloroform layer was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue thus obtained was separated and purified by silica gel chromatography using a solution of hexane/ethyl acetate (10/1 by volume) as a developing solvent. Thus, 5.40 g of the desired compound was obtained in the form of a colorless oily substance. Yield: 80%.

Quelle