Reaktion #574069

Reaktionsgleichung

HCl

water

2-(4-aminophenoxy)-2-methylpropionic acid

3,5-dichlorophenyl isocyanate

→

2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Waschenwashed several times with cold water
3. 3
   Sonstigedried
4. 4
   SonstigeRecrystallization from aqueous acetone
5. 5
   Sonstigegave small plates 1.81 g (94%) MP 182°-184°

Vorschrift

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.

Quelle