Reaktion #573179

Reaktionsgleichung

5-[3-(S)-fluoroheptyloxy]-2-(4-hydroxyphenyl)pyrimidine

potassium carbonate

DMF

2-(S)-tetrahydropyranyloxyheptyl tosylate

→

titled compound

Ausbeute 110.7%

5-[3-(S)-Fluoroheptyloxy]-2-[4-{2-(S)-tetrahydropyranyloxyheptyloxy}phenyl]-pyrimidine

Ausbeute 110.7%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto react at 80° C. for one day
2. 2
   TemperaturAfter cooling
3. 3
   Extraktionthe reaction mixture was extracted with toluene
4. 4
   Sonstigethe solvent was removed from the
5. 5
   Extraktionextract
6. 6
   Sonstigeto obtain 7.6 g of a crude product
7. 7
   SonstigePurification by silica gel column chromatography

Vorschrift

In a reaction flask were charged 3.5 g of 5-[3-(S)-fluoroheptyloxy]-2-(4-hydroxyphenyl)pyrimidine synthesized in the same manner as in steps 1 to 7 of Example 1, 3.17 g of potassium carbonate, 70 ml of DMF, and 6.4 g of 2-(S)-tetrahydropyranyloxyheptyl tosylate in a nitrogen stream, and the mixture was allowed to react at 80° C. for one day. After cooling, water was added thereto, the reaction mixture was extracted with toluene, and the solvent was removed from the extract to obtain 7.6 g of a crude product. Purification by silica gel column chromatography gave 6.4 g of the titled compound.

Quelle