Reaktion #573177

Reaktionsgleichung

5-hydroxy-2-(4-benzyloxyphenyl)pyrimidine

(R)-2-tetrahydropyranyloxyheptyl tosylate

potassium carbonate

→

titled compound

Ausbeute 121.5%

5-[2-(R)-Tetrahydropyranyloxyheptyloxy]-2-(4-benzyloxyphenyl)pyrimidine

Ausbeute 121.5%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   WaschenThe extract was washed with water
4. 4
   Sonstigethe solvent was removed by distillation under reduced pressure
5. 5
   Sonstigeto obtain 28.6 g of a crude product, which
6. 6
   Sonstigewas purified by silica gel column chromatography

Vorschrift

In a 500 ml four-necked flask were charged 12.2 g (43.7 mmol) of 5-hydroxy-2-(4-benzyloxyphenyl)pyrimidine, 24 g (65.5 mmol) of (R)-2-tetrahydropyranyloxyheptyl tosylate, 12 g of potassium carbonate, and 183 ml of DMF, and the mixture was stirred at 80° C. for 5 hours. After cooling, the reaction mixture was poured into 500 ml of ice-water and extracted with ethyl acetate. The extract was washed with water, and the solvent was removed by distillation under reduced pressure to obtain 28.6 g of a crude product, which was purified by silica gel column chromatography to obtain 25.3 g of the titled compound.

Quelle