Reaktion #572884

Reaktionsgleichung

9-Hydroxy-9H-fluorene-9-carboxylic acid

hydrogen chloride

methanol

→

9-Hydroxy-9H-fluorene-9-carboxylic acid methyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 4 h
2. 2
   SonstigeThe crystalline material obtained
3. 3
   Temperaturon cooling
4. 4
   Filtrationwas collected by filtration
5. 5
   Waschenwashed with cold 1:1 ethyl acetate/hexane
6. 6
   Sonstigeto provide
7. 7
   Trocknenafter drying (1), 15.8 g (74%)

Vorschrift

9-Hydroxy-9H-fluorene-9-carboxylic acid (Aldrich Chemical, Inc.) (20.0 g, 88.4 mmol) was added to 100 mL methanol saturated with hydrogen chloride and mixture was stirred at reflux for 4 h. The crystalline material obtained on cooling was collected by filtration and washed with cold 1:1 ethyl acetate/hexane to provide after drying (1), 15.8 g (74%).

Quelle