Reaktion #572859

Reaktionsgleichung

Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline, dihydrobromide salt

ethanol

ammonium hydroxide

thiourea

→

Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline

Lösungsmittel

chloroform methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe product isolated
2. 2
   Sonstigewas twice crystallized from methanol
3. 3
   Sonstigeto yield 0.61 g
4. 4
   Sonstigemelting above 235° C
5. 5
   Sonstigegave a single spot

Vorschrift

About 10.8 millimole of the above hydrobromide salt were dissolved in 30 ml. of anhydrous ethanol to which had been added 1.03 g. of thiourea. The reaction was carried out and the product isolated according to the procedure of Example 1. Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline, dihydrobromide salt thus prepared was twice crystallized from methanol to yield 0.61 g. of a colorless crystalline solid melting above 235° C. TLC using 4:1 chloroform-methanol with a trace of aqueous ammonium hydroxide as the solvent system gave a single spot; Rf =0.30.

Quelle