Reaktion #572394

Reaktionsgleichung

2-chloro-5-nitrophenol

ethyl α-bromopropionate

potassium carbonate

→

ethyl α-(2-chloro-5-nitrophenoxy)propionate

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 17.4 g
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   workup.ADDITION2N-HCl was added to the residue
4. 4
   Sonstigeto obtain a crude crystal
5. 5
   SonstigeThe product was separated by a filtration
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried
8. 8
   Sonstigerecrystallized from n-hexane
9. 9
   Sonstigeto obtain 27.4 g

Vorschrift

A mixture of 17.4 g. of 2-chloro-5-nitrophenol, 19.0 g. of ethyl α-bromopropionate, 15.2 g. of potassium carbonate and 85 ml. of acetone was refluxed with stirring for 3.5 hours and the solvent was distilled off. 2N-HCl was added to the residue to obtain a crude crystal. The product was separated by a filtration and washed with water and dried and recrystallized from n-hexane to obtain 27.4 g. of the object compound (melting point of 46° to 46.5° C.).

Quelle