Reaktion #57220

ord-c8625d8c24db405096fb0310fb0f8150

Reaktionsgleichung

Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(N)cc4)ccnc32)cc1
4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline
CNC
dimethylamine
C1CCOC1
tetrahydrofuran
→
Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(NC(=O)N(C)C)cc4)ccnc32)cc1
title compound
Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(NC(=O)N(C)C)cc4)ccnc32)cc1
N,N-dimethyl-N′-[4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)phenyl]urea

Edukte

Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(N)cc4)ccnc32)cc1
4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline
CNC
dimethylamine
C1CCOC1
tetrahydrofuran

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure in Example 5a with 4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline and 2M dimethylamine in tetrahydrofuran provided the title compound. ESMS [M+H]+: 532.2

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419988B2uspto-grants-2008_09