Reaktion #57219

ord-90b3b011b46648799017b743bd01cb69

Reaktionsgleichung

Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(N)cc4)ccnc32)cc1
4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline
CCN=C=O
ethyl isocyanate
→
CCNC(=O)Nc1ccc(-c2nc(C)sc2-c2ccnc3c2ccn3S(=O)(=O)c2ccc(C)cc2)cc1
title product
CCNC(=O)Nc1ccc(-c2nc(C)sc2-c2ccnc3c2ccn3S(=O)(=O)c2ccc(C)cc2)cc1
N-ethyl-N′-[4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)phenyl]urea

Edukte

Cc1ccc(S(=O)(=O)n2ccc3c(-c4sc(C)nc4-c4ccc(N)cc4)ccnc32)cc1
4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline
CCN=C=O
ethyl isocyanate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure described in Example 1 with 4-(2-methyl-5-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-4-yl)aniline and ethyl isocyanate provided the title product. ESMS [M+H]+: 532.2

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419988B2uspto-grants-2008_09