Reaktion #57217

Reaktionsgleichung

Bromine

2-methyl-4-(4-nitrophenyl)-1,3-thiazole

→

title compound

Ausbeute 60.0%

5-bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole

Ausbeute 60.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe solution refluxed for 4 h
2. 2
   SonstigeThe solvent was evaporated
3. 3
   Sonstigethe product purified by crystallization from ether

Vorschrift

Bromine (6 mmol) was added dropwise to a solution of 2-methyl-4-(4-nitrophenyl)-1,3-thiazole (5 mmol) in chloroform (20 mL) and the solution refluxed for 4 h. The solvent was evaporated and the product purified by crystallization from ether to afford the title compound (60%). ESMS [M+H]+: 300.2

Quelle