Reaktion #57216

Reaktionsgleichung

3-bromo-(4-nitrophenyl)-ethanone

thioacetamide

Ethyl acetate

→

title product

Ausbeute 80.0%

2-methyl-4-(4-nitrophenyl)-1,3-thiazole

Ausbeute 80.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe solution was washed with water (3×20 mL)
2. 2
   SonstigeThe product was purified by crystallization from ether

Vorschrift

A solution of 3-bromo-(4-nitrophenyl)-ethanone (2.5 mmol) and thioacetamide (3 mmol) in N,N-dimethylformamide (20 mL) was heated at 65° C. for 8 h. Ethyl acetate (40 mL) was added and the solution was washed with water (3×20 mL). The product was purified by crystallization from ether to give the title product (80%). ESMS [M+H]+: 221.2

Quelle