Reaktion #57177

ord-0539bbe2b85a43f186bc7a1656771d83

Reaktionsgleichung

CN(C)C(=O)Nc1ccc(-c2n[nH]cc2-c2ccnc3[nH]c(-c4ccc(C=O)cc4)cc23)cc1
N′-(4-{4-[2-(4-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea
C1CCNC1
pyrrolidine
→
CN(C)C(=O)Nc1ccc(-c2n[nH]cc2-c2ccnc3[nH]c(-c4ccc(CN5CCCC5)cc4)cc23)cc1
title compound
CN(C)C(=O)Nc1ccc(-c2n[nH]cc2-c2ccnc3[nH]c(-c4ccc(CN5CCCC5)cc4)cc23)cc1
N,N-dimethyl-N′-[4-(4-{2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-3-yl)phenyl]urea

Edukte

—
Intermediate 101
CN(C)C(=O)Nc1ccc(-c2n[nH]cc2-c2ccnc3[nH]c(-c4ccc(C=O)cc4)cc23)cc1
N′-(4-{4-[2-(4-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea
C1CCNC1
pyrrolidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure described for Intermediate 101 using N′-(4-{4-[2-(4-formylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea and pyrrolidine provided the title compound. ESMS [M+H]+: 506.4

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419988B2uspto-grants-2008_09