Reaktion #571520

Reaktionsgleichung

cyclohexanecarbonyl chloride

anisole

aluminium chloride

→

4-Methoxyphenyl cyclohexyl ketone

Lösungsmittel

dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITto stand overnight
2. 2
   Extraktionthe aqueous phase is extracted with dichloromethane
3. 3
   WaschenThe organic phase is washed with 1N NaOH and water
4. 4
   Trocknendried over sodium sulphate
5. 5
   Einengenconcentrated in vacuo

Vorschrift

42.6 g (0.291 mol) of cyclohexanecarbonyl chloride and then 30 g (0.277 mol) of anisole are added dropwise at room temperature to a suspension of 44.4 g (0.33 mol) of aluminium chloride in 120 ml of dichloroethane. The reaction mixture is stirred for 1 h and allowed to stand overnight. For working up, the mixture is poured into ice-water and the aqueous phase is extracted with dichloromethane. The organic phase is washed with 1N NaOH and water, dried over sodium sulphate and concentrated in vacuo.

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