Reaktion #571403

Reaktionsgleichung

2-chloro-4-fluoro-5-nitro-thiolbenzoic acid (methoxycarbonylmethyl) ester

hydrogen

→

5-amino-2-chloro-4-fluoro-thiolbenzoic acid (methoxycarbonylmethyl) ester

Ausbeute 89.9%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the stoichiometric amount of hydrogen has been consumed
2. 2
   Sonstigethe catalyst is separated off
3. 3
   Einengenthe solution is concentrated by evaporation

Vorschrift

10.4 g of the 2-chloro-4-fluoro-5-nitro-thiolbenzoic acid (methoxycarbonylmethyl) ester obtained in accordance with Example P1 are hydrogenated with hydrogen under normal pressure in 150 ml of tetrahydrofuran at a temperature of 20°-25° C. in the presence of 2 g of Raney nickel catalyst. After the stoichiometric amount of hydrogen has been consumed, the catalyst is separated off and the solution is concentrated by evaporation, yielding 8.6 g of 5-amino-2-chloro-4-fluoro-thiolbenzoic acid (methoxycarbonylmethyl) ester having a melting point of from +88° to +89° C.

Quelle