Reaktion #57128

ord-ccfe2ed87bdb429b81431409d568a9e0

Reaktionsgleichung

Cl.Cl.OC1(CCc2ccc(OCc3ccccc3C(F)(F)F)cc2)CCCCC1N1CCNCC1
2-piperazin-1-yl-1-(4-{[2-(trifluoromethyl)benzyl]oxy}phenylethyl]cyclohexanol dihydrochloride
CC(C)(C)OC(=O)N1CCN(C(=O)C(c2ccc(OCc3ccccc3C(F)(F)F)cc2)C2(O)CCCCC2)CC1
tert-butyl 4-[(1-hydroxycyclohexyl)(4-{[2-(trifluoromethyl)benzyl]oxy}phenyl)acetyl]piperazine-1-carboxylate
→
Cl.Cl.OC1(C(CN2CCNCC2)c2ccc(OCc3ccccc3C(F)(F)F)cc2)CCCCC1
1-[2-piperazin-1-yl-1-(4-{[2-(trifluoromethyl)benzyl]oxy}phenyl)ethyl]cyclohexanol Dihydrochloride

Edukte

Cl.Cl.OC1(CCc2ccc(OCc3ccccc3C(F)(F)F)cc2)CCCCC1N1CCNCC1
2-piperazin-1-yl-1-(4-{[2-(trifluoromethyl)benzyl]oxy}phenylethyl]cyclohexanol dihydrochloride
CC(C)(C)OC(=O)N1CCN(C(=O)C(c2ccc(OCc3ccccc3C(F)(F)F)cc2)C2(O)CCCCC2)CC1
tert-butyl 4-[(1-hydroxycyclohexyl)(4-{[2-(trifluoromethyl)benzyl]oxy}phenyl)acetyl]piperazine-1-carboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In an analogous manner to Example 1, step 2, 1-[2-piperazin-1-yl-1-(4-{[2-(trifluoromethyl)benzyl]oxy}phenylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[(1-hydroxycyclohexyl)(4-{[2-(trifluoromethyl)benzyl]oxy}phenyl)acetyl]piperazine-1-carboxylate. MS (ES) m/z 463.3; HRMS: calcd for C26H33F3N2O2+H+, 463.25669; found (ESI-FT/MS, [M+H]1+), 463.2574.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419980B2uspto-grants-2008_09